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Semax
Semax is a synthetic peptide originally developed in Russia and studied for its potential effects on the nervous system. Research has explored its role as a neuroprotective and nootropic compound, meaning it may help protect brain cells and support cognitive function. Semax appears to work in part by influencing levels of brain-derived neurotrophic factor (BDNF), a protein involved in learning, memory, and neural plasticity. Studies have investigated its possible applications in areas such as recovery from brain injury, improving focus and attention, and supporting overall brain health.
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What is Semax?
Semax is a synthetic peptide originally developed in Russia and studied for its potential effects on the nervous system. Research has explored its role as a neuroprotective and nootropic compound, meaning it may help protect brain cells and support cognitive function. Semax appears to work in part by influencing levels of brain-derived neurotrophic factor (BDNF), a protein involved in learning, memory, and neural plasticity. Studies have investigated its possible applications in areas such as recovery from brain injury, improving focus and attention, and supporting overall brain health.
Mechanisms of Action
Studies have explored that Semax may help with:
- Supporting memory and learning processes
- Enhancing focus, attention, and mental clarity
- Promoting neuroprotection and recovery after brain injury
- Modulating the brain’s stress response
- Supporting healthy blood flow to the brain
Reducing symptoms of mental fatigue
Molecular Structure of Semax

Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Properties
C₃₇H₅₁N₉O₁₀S
813.929 g/mol
Semax Research Highlights
Studies suggest Semax may improve short-term and long-term memory, enhance attention span, and increase mental clarity, particularly under conditions of stress or fatigue.
Source: pubmed
Research in animal models and human trials has explored Semax’s ability to reduce damage from brain injuries, strokes, and hypoxia by protecting neurons and promoting repair.
Source: pubmed
Semax’s influence on dopamine and serotonin pathways may help stabilize mood and enhance motivation without the side effects of traditional antidepressants.
Source: pubmed
By increasing BDNF expression, Semax supports synaptic plasticity and the brain’s ability to adapt, learn, and recover from injury.
Source: pubmed