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Sermorelin + Ipamorelin (Blend)
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of naturally occurring growth hormone–releasing hormone (GHRH). It stimulates the pituitary gland to release growth hormone (GH) in a natural, pulsatile pattern that closely mimics the body’s own rhythms. Ipamorelin is a selective growth hormone secretagogue (GHS) that activates ghrelin receptors to trigger GH release without significantly affecting cortisol or prolactin levels. In research settings, combining Sermorelin and Ipamorelin is explored for its potential to enhance GH output through dual-pathway stimulation while maintaining a clean hormonal profile.
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What is Sermorelin + Ipamorelin (Blend)?
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of naturally occurring growth hormone–releasing hormone (GHRH). It stimulates the pituitary gland to release growth hormone (GH) in a natural, pulsatile pattern that closely mimics the body’s own rhythms. Ipamorelin is a selective growth hormone secretagogue (GHS) that activates ghrelin receptors to trigger GH release without significantly affecting cortisol or prolactin levels. In research settings, combining Sermorelin and Ipamorelin is explored for its potential to enhance GH output through dual-pathway stimulation while maintaining a clean hormonal profile.
Mechanisms of Action
Sermorelin + Ipamorelin may work together by:
- Sermorelin: Binding to GHRH receptors to initiate physiologic GH pulses
- Ipamorelin: Activating ghrelin receptors (GHS-R1a) to increase GH pulse amplitude and frequency without large side hormone spikes
- Increasing circulating IGF-1 to support protein synthesis, muscle repair, and tissue regeneration
- Enhancing collagen production, joint health, and recovery capacity in research models
- Supporting fat metabolism and lean muscle preservation through elevated GH and IGF-1
- Providing a balance of frequency (Sermorelin) and amplitude (Ipamorelin) in GH release