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Tesamorelin + Ipamorelin (Blend)
Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) that stimulates the pituitary gland to release growth hormone (GH) through the natural GHRH pathway. It has a 44–amino acid structure with modifications that increase its stability and half-life compared to natural GHRH. Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist that triggers GH release via a separate pathway from GHRH. When used together in research settings, Tesamorelin and Ipamorelin may have complementary effects on GH release by acting on two different hormonal signaling mechanisms.
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What is Tesamorelin + Ipamorelin (Blend)?
Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) that stimulates the pituitary gland to release growth hormone (GH) through the natural GHRH pathway. It has a 44–amino acid structure with modifications that increase its stability and half-life compared to natural GHRH. Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist that triggers GH release via a separate pathway from GHRH. When used together in research settings, Tesamorelin and Ipamorelin may have complementary effects on GH release by acting on two different hormonal signaling mechanisms.
Mechanisms of Action
Tesamorelin + Ipamorelin may work together by:
- Tesamorelin: Binding to GHRH receptors in the pituitary to increase GH pulse amplitude and frequency
- Ipamorelin: Activating ghrelin receptors (GHS-R1a) to enhance GH secretion without significantly affecting cortisol or prolactin levels
- Potentially increasing circulating insulin-like growth factor-1 (IGF-1) to support tissue growth and repair
- Acting synergistically to promote a greater and more sustained GH release than either peptide alone
- Supporting protein synthesis, tissue recovery, and metabolic regulation in research models